Antimalarial Resistance in Ethiopia

Using samples collected as part of antimalarial drug efficacy studies across Ethiopia over multiple years, we demonstrated that P. falciparum parasites have evidence of persistence through space and time, despite differing profiles of antimalarial resistance. A main focus of this project was capacity building and increased molecular surveillance capacity at the Ethiopian Public Health Institute and was the first project of a lasting collaboration between the EPHI and UNC. This project was published in the American Journal of Tropical Medicine & Hygeine1.

  1. Brazeau NF, Assefa A, Mohammed H, Seme H, Tsadik AG, Parr JB, Keeler C, Hathaway NJ, Meshnick SR, Bailey JA, Kassa M, Juliano JJ, Woyessa A. Pooled Deep Sequencing of Drug Resistance Loci from Plasmodium falciparum Parasites across Ethiopia. Am J Trop Med Hyg. 2019 Nov;101(5):1139-1143. doi: 10.4269/ajtmh.19-0142. PMID: 31516103; PMCID: PMC6838589. ↩︎

Nicholas Brazeau
Resident Physician