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Selective sweep suggests transcriptional regulation may underlie Plasmodium vivax resilience to malaria control measures in Cambodia - PubMed

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Reassessing Reported Deaths and Estimated Infection Attack Rate during the First 6 Months of the COVID-19 Epidemic, Delhi, India

India reported textgreater10 million coronavirus disease (COVID-19) cases and 149,000 deaths in 2020. To reassess reported deaths and …
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Estimating the COVID-19 infection fatality ratio accounting for seroreversion using statistical modelling

Background: The infection fatality ratio (IFR) is a key statistic for estimating the burden of coronavirus disease 2019 (COVID-19) and …
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Household Prevalence of Plasmodium falciparum, Plasmodium vivax, and Plasmodium ovale in the Democratic Republic of the Congo, 2013-2014

In a cross-sectional molecular study in the Democratic Republic of the Congo, 78% of households had ≥1 member infected with Plasmodium …
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The epidemiology of Plasmodium vivax among adults in the Democratic Republic of the Congo

Reports of P. vivax infections among Duffy-negative hosts have accumulated throughout sub-Saharan Africa. Despite this growing body of …
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Modelling intensive care unit capacity under different epidemiological scenarios of the COVID-19 pandemic in three Western European countries

BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has placed enormous strain on intensive care units (ICUs) in Europe. …
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Using syndromic measures of mortality to capture the dynamics of COVID-19 in Java, Indonesia, in the context of vaccination rollout

BACKGROUND: As in many countries, quantifying COVID-19 spread in Indonesia remains challenging due to testing limitations. In Java, …
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The Burden of Malaria in the Democratic Republic of the Congo

Despite evidence that older children and adolescents bear the highest burden of malaria, large malaria surveys focus on younger …
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Within-country age-based prioritisation, global allocation, and public health impact of a vaccine against SARS-CoV-2: A mathematical modelling analysis

The worldwide endeavour to develop safe and effective COVID-19 vaccines has been extraordinary, and vaccination is now underway in many …
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Leveraging community mortality indicators to infer COVID-19 mortality and transmission dynamics in Damascus, Syria

The COVID-19 pandemic has resulted in substantial mortality worldwide. However, to date, countries in the Middle East and Africa have …
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Under the Radar: Epidemiology of Plasmodium ovale in the Democratic Republic of the Congo

BACKGROUND: Plasmodium ovale is an understudied malaria species prevalent throughout much of sub-Saharan Africa. Little is known about …
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Selection of Cytochrome b Mutants Is Rare among Plasmodium falciparum Patients Failing Treatment with Atovaquone-Proguanil in Cambodia

Atovaquone-proguanil remains effective against multidrug-resistant Plasmodium falciparum in Southeast Asia, but resistance is mediated …
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Reduction in mobility and COVID-19 transmission

In response to the COVID-19 pandemic, countries have sought to control SARS-CoV-2 transmission by restricting population movement …
Pierre Nouvellet, Sangeeta Bhatia, Anne Cori, Kylie E. C. Ainslie, Marc Baguelin, Samir Bhatt, Adhiratha Boonyasiri, Nicholas F. Brazeau, Lorenzo Cattarino, Laura V. Cooper, Helen Coupland, Zulma M. Cucunuba, Gina Cuomo-Dannenburg, Amy Dighe, Bimandra A. Djaafara, Ilaria Dorigatti, Oliver D. Eales, Sabine L. van Elsland, Fabricia F. Nascimento, Richard G. FitzJohn, Katy A. M. Gaythorpe, Lily Geidelberg, William D. Green, Arran Hamlet, Katharina Hauck, Wes Hinsley, Natsuko Imai, Benjamin Jeffrey, Edward Knock, Daniel J. Laydon, John A. Lees, Tara Mangal, Thomas A. Mellan, Gemma Nedjati-Gilani, Kris V. Parag, Margarita Pons-Salort, Manon Ragonnet-Cronin, Steven Riley, H. Juliette T. Unwin, Robert Verity, Michaela A. C. Vollmer, Erik Volz, Patrick G. T. Walker, Caroline E. Walters, Haowei Wang, Oliver J. Watson, Charles Whittaker, Lilith K. Whittles, Xiaoyue Xi, Neil M. Ferguson, Christl A. Donnelly
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Database of epidemic trends and control measures during the first wave of COVID-19 in mainland China

OBJECTIVES: In this data collation study, we aimed to provide a comprehensive database describing the epidemic trends and responses …
Han Fu, Haowei Wang, Xiaoyue Xi, Adhiratha Boonyasiri, Yuanrong Wang, Wes Hinsley, Keith J. Fraser, Ruth McCabe, Daniela Olivera Mesa, Janetta Skarp, Alice Ledda, Tamsin Dewé, Amy Dighe, Peter Winskill, Sabine L. van Elsland, Kylie E. C. Ainslie, Marc Baguelin, Samir Bhatt, Olivia Boyd, Nicholas F. Brazeau, Lorenzo Cattarino, Giovanni Charles, Helen Coupland, Zulma M. Cucunuba, Gina Cuomo-Dannenburg, Christl A. Donnelly, Ilaria Dorigatti, Oliver D. Eales, Richard G. FitzJohn, Seth Flaxman, Katy A. M. Gaythorpe, Azra C. Ghani, William D. Green, Arran Hamlet, Katharina Hauck, David J. Haw, Benjamin Jeffrey, Daniel J. Laydon, John A. Lees, Thomas Mellan, Swapnil Mishra, Gemma Nedjati-Gilani, Pierre Nouvellet, Lucy Okell, Kris V. Parag, Manon Ragonnet-Cronin, Steven Riley, Nora Schmit, Hayley A. Thompson, H. Juliette T. Unwin, Robert Verity, Michaela A. C. Vollmer, Erik Volz, Patrick G. T. Walker, Caroline E. Walters, Oliver J. Watson, Charles Whittaker, Lilith K. Whittles, Natsuko Imai, Sangeeta Bhatia, Neil M. Ferguson
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State-level tracking of COVID-19 in the United States

As of 1st June 2020, the US Centres for Disease Control and Prevention reported 104,232 confirmed or probable COVID-19-related deaths …
H. Juliette T. Unwin, Swapnil Mishra, Valerie C. Bradley, Axel Gandy, Thomas A. Mellan, Helen Coupland, Jonathan Ish-Horowicz, Michaela A. C. Vollmer, Charles Whittaker, Sarah L. Filippi, Xiaoyue Xi, Mélodie Monod, Oliver Ratmann, Michael Hutchinson, Fabian Valka, Harrison Zhu, Iwona Hawryluk, Philip Milton, Kylie E. C. Ainslie, Marc Baguelin, Adhiratha Boonyasiri, Nick F. Brazeau, Lorenzo Cattarino, Zulma Cucunuba, Gina Cuomo-Dannenburg, Ilaria Dorigatti, Oliver D. Eales, Jeffrey W. Eaton, Sabine L. van Elsland, Richard G. FitzJohn, Katy A. M. Gaythorpe, William Green, Wes Hinsley, Benjamin Jeffrey, Edward Knock, Daniel J. Laydon, John Lees, Gemma Nedjati-Gilani, Pierre Nouvellet, Lucy Okell, Kris V. Parag, Igor Siveroni, Hayley A. Thompson, Patrick Walker, Caroline E. Walters, Oliver J. Watson, Lilith K. Whittles, Azra C. Ghani, Neil M. Ferguson, Steven Riley, Christl A. Donnelly, Samir Bhatt, Seth Flaxman
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SARS-CoV-2 infection prevalence on repatriation flights from Wuhan City, China

Hayley A. Thompson, Natsuko Imai, Amy Dighe, Kylie E. C. Ainslie, Marc Baguelin, Sangeeta Bhatia, Samir Bhatt, Adhiratha Boonyasiri, Olivia Boyd, Nicholas F. Brazeau, Lorenzo Cattarino, Laura V. Cooper, Helen Coupland, Zulma Cucunuba, Gina Cuomo-Dannenburg, Bimandra Djaafara, Ilaria Dorigatti, Sabine van Elsland, Richard FitzJohn, Han Fu, Katy A. M. Gaythorpe, Will Green, Timothy Hallett, Arran Hamlet, David Haw, Sarah Hayes, Wes Hinsley, Benjamin Jeffrey, Edward Knock, Daniel J. Laydon, John Lees, Tara D. Mangal, Thomas Mellan, Swapnil Mishra, Andria Mousa, Gemma Nedjati-Gilani, Pierre Nouvellet, Lucy Okell, Kris V. Parag, Manon Ragonnet-Cronin, Steven Riley, H. Juliette T. Unwin, Robert Verity, Michaela Vollmer, Erik Volz, Patrick G. T. Walker, Caroline Walters, Haowei Wang, Yuanrong Wang, Oliver J. Watson, Charles Whittaker, Lilith K. Whittles, Peter Winskill, Xiaoyue Xi, Christl A. Donnelly, Neil M. Ferguson
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Comparison of molecular testing strategies for COVID-19 control: a mathematical modelling study

BACKGROUND: WHO has called for increased testing in response to the COVID-19 pandemic, but countries have taken different approaches …
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Response to COVID-19 in South Korea and implications for lifting stringent interventions

BACKGROUND: After experiencing a sharp growth in COVID-19 cases early in the pandemic, South Korea rapidly controlled transmission …
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Potential impact of the COVID-19 pandemic on HIV, tuberculosis, and malaria in low-income and middle-income countries: a modelling study

BACKGROUND: COVID-19 has the potential to cause substantial disruptions to health services, due to cases overburdening the health …
Alexandra B. Hogan, Britta L. Jewell, Ellie Sherrard-Smith, Juan F. Vesga, Oliver J. Watson, Charles Whittaker, Arran Hamlet, Jennifer A. Smith, Peter Winskill, Robert Verity, Marc Baguelin, John A. Lees, Lilith K. Whittles, Kylie E. C. Ainslie, Samir Bhatt, Adhiratha Boonyasiri, Nicholas F. Brazeau, Lorenzo Cattarino, Laura V. Cooper, Helen Coupland, Gina Cuomo-Dannenburg, Amy Dighe, Bimandra A. Djaafara, Christl A. Donnelly, Jeff W. Eaton, Sabine L. van Elsland, Richard G. FitzJohn, Han Fu, Katy A. M. Gaythorpe, William Green, David J. Haw, Sarah Hayes, Wes Hinsley, Natsuko Imai, Daniel J. Laydon, Tara D. Mangal, Thomas A. Mellan, Swapnil Mishra, Gemma Nedjati-Gilani, Kris V. Parag, Hayley A. Thompson, H. Juliette T. Unwin, Michaela A. C. Vollmer, Caroline E. Walters, Haowei Wang, Yuanrong Wang, Xiaoyue Xi, Neil M. Ferguson, Lucy C. Okell, Thomas S. Churcher, Nimalan Arinaminpathy, Azra C. Ghani, Patrick G. T. Walker, Timothy B. Hallett
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The impact of COVID-19 and strategies for mitigation and suppression in low- and middle-income countries

The ongoing coronavirus disease 2019 (COVID-19) pandemic poses a severe threat to public health worldwide. We combine data on …
Patrick G. T. Walker, Charles Whittaker, Oliver J. Watson, Marc Baguelin, Peter Winskill, Arran Hamlet, Bimandra A. Djafaara, Zulma Cucunubá, Daniela Olivera Mesa, Will Green, Hayley Thompson, Shevanthi Nayagam, Kylie E. C. Ainslie, Sangeeta Bhatia, Samir Bhatt, Adhiratha Boonyasiri, Olivia Boyd, Nicholas F. Brazeau, Lorenzo Cattarino, Gina Cuomo-Dannenburg, Amy Dighe, Christl A. Donnelly, Ilaria Dorigatti, Sabine L. van Elsland, Rich FitzJohn, Han Fu, Katy A. M. Gaythorpe, Lily Geidelberg, Nicholas Grassly, David Haw, Sarah Hayes, Wes Hinsley, Natsuko Imai, David Jorgensen, Edward Knock, Daniel Laydon, Swapnil Mishra, Gemma Nedjati-Gilani, Lucy C. Okell, H. Juliette Unwin, Robert Verity, Michaela Vollmer, Caroline E. Walters, Haowei Wang, Yuanrong Wang, Xiaoyue Xi, David G. Lalloo, Neil M. Ferguson, Azra C. Ghani
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Spatial and epidemiological drivers of Plasmodium falciparum malaria among adults in the Democratic Republic of the Congo

BACKGROUND: Adults are frequently infected with malaria and may serve as a reservoir for further transmission, yet we know relatively …
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The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC

The Democratic Republic of the Congo (DRC) harbors 11% of global malaria cases, yet little is known about the spatial and genetic …
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Loss of daptomycin susceptibility in clinical Staphylococcus epidermidis infection coincided with variants in WalK

Daptomycin (DAP) is key in treating multidrug-resistant Staphylococcus infections. Diminished susceptibility to DAP is emerging among …
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Falciparum malaria from coastal Tanzania and Zanzibar remains highly connected despite effective control efforts on the archipelago

BACKGROUND: Tanzania’s Zanzibar archipelago has made significant gains in malaria control over the last decade and is a target …
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Anonymised and aggregated crowd level mobility data from mobile phones suggests that initial compliance with COVID-19 social distancing interventions was high and geographically consistent across the UK

Background: Since early March 2020, the COVID-19 epidemic across the United Kingdom has led to a range of social distancing policies, …
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Pooled Deep Sequencing of Drug Resistance Loci from Plasmodium falciparum Parasites across Ethiopia

Although Ethiopia has an overall lower prevalence of Plasmodium falciparum among countries in Africa, the emergence of drug resistance …
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The changing landscape of Plasmodium falciparum drug resistance in the Democratic Republic of Congo

BACKGROUND: Drug resistant malaria is a growing concern in the Democratic Republic of the Congo (DRC), where previous studies indicate …
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Prevalence of Molecular Markers of Antimalarial Drug Resistance across Altitudinal Transmission Zones in Highland Western Uganda

We explored spatial variation in the prevalence of established molecular markers of antimalarial resistance across a geographically …
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Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross

Mainstay treatment for Plasmodium vivax malaria has long relied on chloroquine (CQ) against blood-stage parasites plus primaquine …
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Plasmodium vivax Infections in Duffy-Negative Individuals in the Democratic Republic of the Congo

Although Plasmodium vivax has been assumed to be absent from sub-Saharan Africa because of the protective mutation conferring the …
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Implementation and Evaluation of Shared Medical Appointments for Type 2 Diabetes at a Free, Student-Run Clinic in Alamance County, North Carolina

INTRODUCTION: Type 2 diabetes is a significant problem among uninsured patients. Shared medical appointments (SMA) have been shown to …

Partner-Drug Resistance and Population Substructuring of Artemisinin-Resistant Plasmodium falciparum in Cambodia

Plasmodium falciparum in western Cambodia has developed resistance to artemisinin and its partner drugs, causing frequent treatment …
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Longitudinal Pooled Deep Sequencing of the Plasmodium vivax K12 Kelch Gene in Cambodia Reveals a Lack of Selection by Artemisinin

The emergence of artemisinin resistance among Plasmodium falciparum in the Greater Mekong subregion threatens malaria control …
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Distribution of a Chimpanzee Social Custom Is Explained by Matrilineal Relationship Rather Than Conformity

High-arm grooming is a form of chimpanzee grooming in which two individuals mutually groom while each raising one arm. Palm-to-palm …
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Exclusive Breastfeeding and Clinical Malaria Risk in 6-Month-Old Infants: A Cross-Sectional Study from Kinshasa, Democratic Republic of the Congo

The World Health Organization recommends exclusive breastfeeding (EBF) for the first 6 months of life. However, the effect of EBF on …
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Pooled Amplicon Deep Sequencing of Candidate Plasmodium falciparum Transmission-Blocking Vaccine Antigens

Polymorphisms within Plasmodium falciparum vaccine candidate antigens have the potential to compromise vaccine efficacy. Understanding …
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Dental eruption in East African wild chimpanzees

Knowledge of chimpanzee development has played an essential role in our understanding of the evolution of human ontogeny. However, …
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Critical limb ischemia: an update for interventional radiologists

Critical limb ischemia (CLI) is a growing epidemic with bleak patient outcomes. A variety of treatment modalities have been adopted to …
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May-Thurner syndrome: diagnosis and management

For over fifty years, the pathogenesis of May-Thurner syndrome (MTS) has been associated with chronic left common iliac vein …
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May-Thurner syndrome: can it be diagnosed by a single MR venography study?

PURPOSE: We aimed to evaluate the longitudinal stability of left common iliac vein (LCIV) compression by the right common iliac artery …
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