The Hidden Complexity Inside When a mosquito infected with malaria bites a person, we typically think of it as transmitting “malaria.” But the reality is far more complex. That single mosquito bite might be transmitting one parasite strain—or five, or ten distinct genetic clones simultaneously.
Complexity of Infection (COI) is the number of genetically distinct malaria parasite clones present in a single infection. Understanding COI is crucial for:
Transmission intensity assessment — High COI indicates high transmission Drug resistance monitoring — Polyclonal infections complicate resistance detection Vaccine evaluation — Multiple strains can confound efficacy estimates Elimination strategies — Low COI suggests transmission can be interrupted But measuring COI is surprisingly challenging.
This study uses mortuary and burial data to assess the impact of COVID-19 in Lusaka, Zambia, and places it within a global context. By analyzing mortality patterns, we provide insights into the pandemic burden in sub-Saharan Africa where traditional …
In response to the COVID-19 pandemic, countries have sought to control SARS-CoV-2 transmission by restricting population movement through social distancing interventions, thus reducing the number of contacts. Mobility data represent an important …
The ongoing coronavirus disease 2019 (COVID-19) pandemic poses a severe threat to public health worldwide. We combine data on demography, contact patterns, disease severity, and health care capacity and quality to understand its impact and inform …