This study examines the impact of antimalarial resistance on the genetic structure of Plasmodium falciparum populations in the Democratic Republic of the Congo. Using population genetic approaches, we demonstrate how drug resistance shapes parasite …
This study examines the often-overlooked epidemiology of Plasmodium ovale infections in the Democratic Republic of the Congo. P. ovale has received limited attention compared to P. falciparum and P. vivax, yet understanding its distribution and …
Presentation of the first aim of my PhD dissertation, which focused on the epidemiology of P. vivax in the Democratic Republic of the Congo, at the annual American Society of Tropical Medicine and Hygiene conference. This work is now published in Nature Communications1.
Brazeau NF, Mitchell CL, Morgan AP, Deutsch-Feldman M, Watson OJ, Thwai KL, Gelabert P, van Dorp L, Keeler CY, Waltmann A, Emch M, Gartner V, Redelings B, Wray GA, Mwandagalirwa MK, Tshefu AK, Likwela JL, Edwards JK, Verity R, Parr JB, Meshnick SR, Juliano JJ.
Although Ethiopia has an overall lower prevalence of Plasmodium falciparum among countries in Africa, the emergence of drug resistance could seriously hinder elimination efforts. Using samples collected from five therapeutic efficacy studies …
We explored spatial variation in the prevalence of established molecular markers of antimalarial resistance across a geographically diverse, highland region of western Uganda. We identified Plasmodium falciparum CQ resistance transporter 76T …
BACKGROUND: Drug resistant malaria is a growing concern in the Democratic Republic of the Congo (DRC), where previous studies indicate that parasites resistant to sulfadoxine/pyrimethamine or chloroquine are spatially clustered. This study explores …
Mainstay treatment for Plasmodium vivax malaria has long relied on chloroquine (CQ) against blood-stage parasites plus primaquine against dormant liver-stage forms (hypnozoites), however drug resistance confronts this regimen and threatens malaria …
Although Plasmodium vivax has been assumed to be absent from sub-Saharan Africa because of the protective mutation conferring the Duffy-negative phenotype, recent evidence has suggested that P. vivax cases are prevalent in these regions. We selected …
Presentation at the annual Genomic Epidemiology of Malaria conference presenting early work on polyIBD a hidden Markov model for inferring identity by descent in polyclonal infections using a Bayesian framework. This project is currently in preparation.
Oral presentation at the annual American Society of Tropical Medicine and Hygiene conference analyzing the genomics of P. vivax relapses from Cambodia.